Organocatalytic dynamic kinetic resolution via conjugate addition: synthesis of chiral trans-2,5-dialkylcyclohexanones.
نویسندگان
چکیده
A novel strategy of initiating an organocatalysed dynamic kinetic resolution (dr up to 99 : 1 and er up to 94 : 6) for the synthesis of chiral trans-2,5-dialkylcyclohexanones by an asymmetric conjugate addition of dimethyl malonate on to 6-substituted cyclohexenones is reported.
منابع مشابه
Organocatalytic kinetic resolution via intramolecular aldol reactions: enantioselective synthesis of both enantiomers of chiral cyclohexenones.
Kinetic resolution of 6-aryl-2,6-hexanediones was achieved with chiral secondary amine catalyzed intramolecular aldolization. The current kinetic resolution protocol enables the synthesis of both enantiomers of cyclohexenones with moderate to good enantioselectivity.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 41 شماره
صفحات -
تاریخ انتشار 2012